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The linear calibration ranges were 0.50–500 ng/mL for prednisolone and 0.27–543 ng/mL for cortisol. The precision (RSD%) was for prednisolone in the range of 1.6–11% and for cortisol 1.3–10%. The accuracy was for prednisolone in the range of 87–108% and for cortisol 87–104%.
However, also the potency value (IC50/EC50-value) BSV was quite substantial in this study with greatest values for cortisol response. It is known that PD usually show larger variability between individuals than PK . To the best of our knowledge no BSV-values are published for glucocorticoid responses in dogs. The reason behind this variation is not fully known but sex and age has been shown to be sources of variation in cortisol concentration in dogs . In the present study, age and sex were evaluated as covariates but could not explain the large BSV.
The dogs were housed in groups of two to four dogs for social and welfare reasons. Following oral administration prednisolone is well absorbed from the gastrointestinal tract and distributes in all tissues, in the body fluids and even in the cerebrospinal fluid. It is metabolized in the liver and excretion takes place mainly via the kidneys. Phenytoin, barbiturates, ephedrine and rifampicin, may accelerate the metabolic clearance of corticosteroids resulting in decreased blood levels and reduced physiological effect. Do not stop taking prednisolone suddenly if you've been on it for more than 3 weeks or have taken high doses for more than 1 week.
Do not use in animals suffering from viral or mycotic infections that are not controlled with an appropriate treatment. Population characteristics, prednisolone doses and treatment order. The dedicated veterinary prescription and non-prescription online store. Prednisolone 5mg Tablets are manufactured by Douglas Pharmacuticals and developed specifically for dogs. Please clock add a new pet to eneter the details of the animals you wish to use this product on. This is a POM-V Product (Prescription Only Medication-Veterinary).
Corticosteroids, including prednisolone, can raise blood sugar levels, exacerbate existing diabetes and increase the risk of developing diabetes in patients on long-term corticosteroid therapy. Pheochromocytoma-related crisis, which may be fatal, has been reported following systemic corticosteroid administration. Corticosteroids should only be administered to patients with suspected or identified pheochromocytoma following consideration of individual risk / benefit. The use of prednisolone in active tuberculosis should be limited to those cases of fulminant or disseminated tuberculosis where the corticosteroid is used to treat the disease in combination with appropriate tuberculosis therapy.
As an anti-inflammatory and anti-allergic agent for use in dogs and cats. As an anti-inflammatory and anti-allergic agent for use in cats and dogs. This veterinary medicinal product does not require any special temperature storage conditions.
Prednisolone phosphate is rapidly converted to prednisolone in dogs which was interpreted as the entire prednisolone dose was made systemically available. The succinate ester has also been shown to be rapidly hydrolysed in vivo in rabbits but not in vitro in plasma or whole blood indicating that the active compound probably becomes systemically available due to organ clearance . In dogs, however, the fraction of the dose methylprednisolone made systemically available was 43% after IV administration of methylprednisolone succinate .
The dose should be gradually reduced until the lowest dose which will maintain an adequate clinical response is reached. As a guide, the daily dose should be reduced by 2.5 – 5 mg every second to fifth day until the lowest possible maintenance dose is reached. Use of the lowest effective dose will tend to minimise side-effects. The incidence of side-effects increases with dose and duration of treatment (see Section 4.4 'Special warnings and special precautions for use').
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